Selected publications from ERI affiliated faculty

Joseph Angleson, Ph.D.

Overlease RL, Bauer RA, Angleson JK (2005). Retention of peptide hormone during partial secretion in pituitary somatotrophs and corticotrophs. Eur J Physiol (Pfluger’s Arch) 449, 458-62

Bauer RA, Overlease RL, Lieber JL, Angleson JK (2004). Retention and stimulus-dependent recycling of dense core vesicle content in neuroendocrine cells. J of Cell Sci 117, 2193-2202

Bauer RA, Khera RS, Lieber JL, Angleson JK (2004). Recycling of intact dense core vesicles in neurites of NGF-treated PC12 cells. FEBS Lett 571, 107-111

Vo YP, Hutton JC, Angleson JK (2004). Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. Biochem Biophy Res Com 324, 1004-1010

Zahn TR, Angleson JK, MacMorris MA, Domke1 E, Hutton JF, Schwartz C, Hutton JC (2004). Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104. Traffic 5, 544-559

Wan Y, Angleson JK, Kutateladze AG (2002). Liposomes from novel photolabile phospholipids: light-induced unloading of small molecules as monitored by PFG NMR. J Am Chem Soc 124, 5610-5611

Angleson JK, Betz WJ (2001). Intraterminal Ca2+ and spontaneous transmitter release at the frog neuromuscular junction. J Neurophysiol 85, 287-294

Kilic G, Angleson JK, Cochilla AJ, Nussinovitch I, Betz WJ (2001). Sustained stimulation of exocytosis triggers continuous membrane retrieval in rat pituitary somatotrophs. J Physiol 532, 771-783.

Cochilla AJ, Angleson JK, Betz WJ (2000). Differential regulation of granule-to-granule and granule-to-plasma membrane fusion during secretion from rat pituitary lactotrophs. J Cell Biol 150, 839-8348

Angleson JK, Cochilla AJ, Kilic G, Nussinovitch I, Betz WJ (1999). Regulation of dense core release from neuroendocrine cells revealed by imaging single events. Nature Neuroscience 2, 440-446

Cochilla AJ, Angleson JK, Betz WJ (1999). Monitoring secretory membrane with FM1-43 fluorescence. Ann Rev Neurosci 22, 1-10

Betz WJ, Angleson JK (1997). Cellular secretion: Now you see it, now you don’t. Nature 388, 423-424

Patrick Bosque, M.D.

Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-DeMasters BK Pape J, Tyler, KL (2007). Lessons from the Colorado Surveillance Program for Chronic Wasting Disease Transmission to Humans: two highly suspicious but negative cases. Arch Neurol 64, 439-441

Tamguney E, Giles K, Bouszmondo-Bernstein E, Bosque P, Safar J, DeArmond S, Miller M, Prusiner S (2006). Transmission of elk and deer prions to transgenic mice. J Virol 80, 9104-9114

MaWhinney S, Pape WJ, Forster JE, Anderson CA, Bosque P, Miller MW. Human prion disease and relative risk associated with chronic wasting disease (2006). Emerg Infect Dis [serial on the Internet]. Available from http://www.cdc.gov/ncidod/EID/vol12no10/06-0019.htm

Bosque P (2005). Molecular types of Creutzfeldt–Jakob disease: the strange diversity of prions. Neurology 65, 1520-1521

Gonzales N, Jarboe E, Kleinschmidt-DeMasters B, Bosque P (2005). Acute multifocal CNS demyelination as first presentation of systemic malignancy. Neurology 65, 166

Hall DA, Leehey MA, Filley CM, Steinbart E, Montine T, Schellenberg GD, Bosque P, Nixon R, Bird T (2005). PRNP H187R mutation associated with neuropsychiatric disorders in childhood and dementia. Neurology 64, 1304-1306

Bosque P (2004). Double blind trial of flupirtine in cretuzfeldt-Jakob disease. (editorial) Neurology 65, 679

Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond SJ, Prusiner SB (2002). Prions in skeletal muscle. Proc Natl Acad Sci U S A 99, 3812-3817

Bosque P (2002). Bovine spongiform encephalopathy, chronic wasting disease, scrapie, and the
threat to humans from prion disease epizootics. Current Neurology and Neuroscience Reports 2, 488-495

Christina M. Coughlan, Ph.D.

Sparvero LJ, Patz S, Brodsky JL, Coughlan CM (2007). Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast. Anal Biochem 370, 162-170

Coughlan CM, Brodsky JL (2005). Use of yeast as a model system to investigate protein conformational diseases. Mol Biotechnol 30, 171-180

Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL (2004). Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. J Biol Chem 279, 15289-15297

Coughlan CM, Brodsky JL (2003). Yeast as a model system to investigate protein conformational diseases. Methods Mol Biol 232, 77-90

Chalasani SH, Baribaud F, Coughlan CM, Sunshine MJ, Lee VM, Doms RW, Littman DR, Raper JA (2003). The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. J Neurosci 23, 4601-4612

Puffer BA, Sharron M, Coughlan CM, Baribaud F, McManus CM, Lee B, David J, Price K, Horuk R, Tsang M, Doms RW (2000). Expression and coreceptor function of APJ for primate immunodeficiency viruses. Virology 276, 435-444

Coughlan CM, McManus CM, Sharron M, Gao Z, Murphy D, Jaffer S, Choe W, Chen W, Hesselgesser J, Gaylord H, Kalyuzhny A, Lee VM, Wolf B, Doms RW, Kolson DL (2000). Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience 97, 591-600

Coughlan CM, Breen KC (2000) Factors influencing the processing and function of the amyloid beta precursor protein--a potential therapeutic target in Alzheimer's disease? 86, 111-145

Budas G, Coughlan CM, Seckl JR, Breen KC (1999). The effect of corticosteroids on amyloid beta precursor protein/amyloid precursor-like protein expression and processing in vivo.
Neurosci Lett 276, 61-64

McFarlane I, Georgopoulou N, Coughlan CM, Gillian AM, Breen KC (1999). The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein. Neuroscience 90, 15-25

Phillip B. Danielson, Ph.D.

Danielson PB, Hong-Yu Sun H-Y, Melton T, Kristinsson, A (2007). Resolving mtDNA mixtures by denaturing high-performance liquid chromatography and linkage phase determination Forensic Science International: Genetics 1, 148–153

Westring CG, Kristinsson R, M.S. Gilbert DS, Danielson PB (2007). Validation of reduced-scale reactions for the quantifilerTM human DNA kit J Forensic Sci 52, 1035-1043

Danielson PB, Kristinsson R, Shelton RJ, LaBerge GS (2005). Separating human DNA mixtures using denaturing high-performance liquid chromatography Expert Rev Mol Diagn 5(1), 53-63

Danielson PB (2002). The cytochrome P450 superfamily: biochemistry, evolution and drug
metabolism in humans Current Drug Metabolism 3, 561-597

James C. Fogleman, Ph.D.

Fogleman JC (2000). Response of Drosophila melanogaster to selection for P450-mediated resistance to isoquinoline alkaloids. Chem Biol Interact 125, 93-105

Danielson PB, Foster JL, McMahill MM, Smith MK, Fogleman JC (1998). Induction by alkaloids and phenobarbital of Family 4 Cytochrome P450s in Drosophila: evidence for involvement in host plant utilization. Mol Gen Genet 259, 54-59

Fogleman JC, Danielson PB, Frank MR (1997). Comparison of Drosophila cytochrome P450 metabolism of natural and model substrates. J Insect Physiol 43, 953-957

Danielson PB, MacIntyre RJ, Fogleman JC (1997). Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome p450s: evidence for involvement in host-plant allelochemical resistance. Proc Natl Acad Sci U S A 94, 10797-10802

Danielson PB, Fogleman JC (1997). Isolation and sequence analysis of cytochrome P450 12B1: the first mitochondrial insect P450 with homology to 1 alpha, 25 dihydroxy-D3 24-hydroxylase.
Insect Biochem Mol Biol 27, 595-604

Catherine B. Kunst, Ph.D.

Kunst CB (2004). Complex genetics of amyotrophic lateral sclerosis. Am J Hum Genet 75, 933-47

Kunst CB, Patterson D (2002). Superoxide Dismutases Wiley Encyclopedia of Molecular Medicine 5, 3059-3061

Kunst CB, Messer L, Gordon J, Haines J, Patterson D (2000). Genetic mapping of a mouse modifier gene that can prevent ALS onset. Genomics 70, 181-189

Kunst CB (2001). A Tale of Two Modifiers: how some genes affect the expression of neurological disease phenotypes http://www.sciencemag.org/feature/plus/sfg/articles/11_02kunst.shtml

Schmidt P, Kunst C, Culotta VC (2000). Copper activation of superoxide dismutase 1 (SOD1) in vivo: Role for protein-protein interactions with the copper chaperone for SOD1. J Biol Chem 275, 33771-33776

Kunst CB, Mezey E, Brownstein MJ, Patterson D (1997). Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions. Nature Genetics 15, 91-95

Daniel A. Linseman Ph.D.

Linseman DA, Loucks FA (2008). Diverse roles of Rho family GTPases in neuronal development, survival, and death. Front Biosci 13, 657-676

Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, and Linseman DA (2007). Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem 282, 29296-29304

Loucks FA, Le SS, Zimmermann AK, Ryan KR, Barth H, Aktories K, Linseman DA (2006). Rho family GTPase inhibition reveals opposing effects of MEK/ERK and JAK/STAT signaling cascades on neuronal survival. J Neurochem 97, 957-967

Brewster JL, Linseman DA, Bouchard RJ, Loucks FA, Esche EA, Precht TA, Heidenreich KA (2006). Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol Cell Neurosci 32, 242-253

Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA (2005). Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem 94, 1025-1039

Zimmermann AK, Loucks FA, Le SS, Butts BD, Florez-McClure ML, Bouchard RJ, Heidenreich KA, Linseman DA (2005). Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim. J Neurochem 94, 22-36

Precht TA, Phelps RA, Linseman DA, Butts BD, Le SS, Laessig TA, Bouchard RJ, Heidenreich KA (2005). The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis. Cell Death Differ 12, 255-265

Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA (2004). Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 24, 9993-10002

Ahmadi F, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM (2003). The pesticide rotenone induces caspase-3- mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem 87, 914-921

Linseman DA, Phelps RA, Bouchard RJ, Le SS, Laessig TA, McClure ML, Heidenreich KA (2002). Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J Neurosci 22, 9287-9297

Linseman DA, McClure ML, Bouchard RJ, Laessig TA, Ahmadi FA, Heidenreich KA (2002). Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor-I- dependent mechanism. J Biol Chem 277, 24546-24553

Nancy M. Lorenzon, Ph.D.

Lorenzon NM, Beam KG (2008). Disease causing mutations of calcium channels. Channels 2:3, 1-17, in press, May/June

Lorenzon NM, Beam KG (2007). Accessibility of targeted DHPR sites to streptavidin and functional effects of binding on EC coupling. J Gen Physiol 130, 379-388

Lorenzon NM, Haarmann CS, Norris EE, Papadopoulos S, Beam KG (2004). Metabolic biotinylation as a probe of supramolecular structure of the triad junction in skeletal muscle. J Biol Chem 279, 44057-44064

Lorenzon NM, Beam KG (2000). Calcium channelopathies. Kidney Int 57, 794-802

Foehring RC, Lorenzon NM (1999). Neuromodulation, development and synaptic plasticity.
Can J Exp Psychol 53, 45-61

Lorenzon NM, Lutz CM, Frankel WN, Beam KG (1998). Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J Neurosci 18, 4482-4489

Lorenzon NM, Foehring RC (1995). Alterations in intracellular calcium chelation reproduce developmental differences in repetitive firing and after hyperpolarizations in rat neocortical neurons. Brain Res Dev Brain Res 84, 192-203

Lorenzon NM, Foehring RC (1995). Characterization of pharmacologically identified voltage-gated calcium channel currents in acutely isolated rat neocortical neurons. II. Postnatal development. J Neurophysiol 73, 1443-1451

Martin M. Margittai, Ph.D.

Chen M, Margittai M, Chen J, Langen R (2007). Investigation of alpha-synuclein fibril structure by site-directed spin labeling. J Biol Chem 282, 24970-24979

Margittai M, Langen R (2006). Spin labeling analysis of amyloids and other protein aggregates.
Methods Enzymol 413, 122-139

Margittai M, Langen R (2006). Side chain-dependent stacking modulates tau filament structure.
J Biol Chem 281, 37820-37827

Margittai M, Langen R (2004). Template-assisted filament growth by parallel stacking of tau.
Proc Natl Acad Sci U S A 101, 10278-10283

Schuette CG, Hatsuzawa K, Margittai M, Stein A, Riedel D, Küster P, König M, Seidel C, Jahn R (2004). Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A 101, 2858-2863

Margittai M, Widengren J, Schweinberger E, Schröder GF, Felekyan S, Haustein E, König M, Fasshauer D, Grubmüller H, Jahn R, Seidel CA (2003). Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1. Proc Natl Acad Sci U S A 100, 15516-15521

Fasshauer D, Margittai M (2004). A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly. J Biol Chem 279, 7613-7621

Margittai M, Fasshauer D, Jahn R, Langen R (2003). The Habc domain and the SNARE core complex are connected by a highly flexible linker. Biochemistry 42, 4009-4014

David Patterson, Ph.D.

Hoger, J Patterson D, Hoger H, Shim K, Bubna-Littitz H, Lubec G. Mice transgenic for reduced folate carrier: an animal model of Down syndrome? (2008). Amino Acids, in press, published online, DOI 10.1007/s00726-008-0091-0

Yu J, Zhang Y, Qi Z, Kurtycz D, Vacano G, Patterson D (2008). Methylation-mediated downregulation of the B-Cell Translocation Gene 3 (BTG3) in breast cancer cells. Gene Expression 14, 173-182

Marshall LJ, Chastain-Moore A, Ohki M, Kitabayashi I, Patterson D, Ornelles DA (2008). RUNX1 permits E4orf6-directed nuclear localization of viral DNA and RNA synthesis. J Virol 82, 6395-6408

Hunsucker SW, Solomon B, Gawryluk J, Geiger JD, Patterson D (2008). Assessment of post mortem changes to the mouse brain proteome. J. Neurochem 105, 725-237

Patterson D, Graham C, Cherian, C, Matherly LH (2008). A humanized mouse model for the reduced folate carrier. Molecular Genetics and Metabolism 93, 95–103

Patterson D, Lott IT (2008). Etiology, Diagnosis, and Development in Down Syndrome, in “Speech and Language Development and Intervention in Down Syndrome and Fragile X Syndrome,” Roberts J, Warren S, & Chapman R, eds., Paul H. Brookes Publishing Co, Inc., Maryland, pp. 3-26

Patterson D (2007). Genetic Mechanisms Involved in the Phenotype of Down Syndrome. Ment Retard Dev Disabil Res Rev 13, 199 – 206

Lott I, Patterson D, Seltzer M (2007). Towards a research agenda for Down syndrome. Ment Retard Dev Disabil Res Rev 13, 288-289

Head E, Lott, IT, Patterson D, Doran E, Haier RJ (2007). Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: Targets for nonpharmacological intervention. Journal of Alzheimer’s Disease 1, 161-176

Patterson D (2006). Aging and Susceptibility to Alzheimer’s Disease, in “Down Syndrome Neurobehavioral Specificity,” Eds Rondal JR, Perera J, Wiley Liss, Publishers, pp 35-51

Spiegel EK, Colman RF, Patterson D (2006). Adenylosuccinate lyase deficiency. Molecular Genetics and Metabolism 89, 19-31

Butler C, Knox, A, Bowersox J, Forbes S, Patterson D (2006). The production of transgenic mice expressing human cystathionine beta-synthase to study Down syndrome. Behav Genet 36, 429-438

Patterson D and Costa AC (2005). Down syndrome and genetics – a case of linked histories. Nature Reviews Genetics 6, 137-147

Sivendran S, Patterson D, Spiegel E, McGown I, Cowley D, Colman RF (2004). Identification of 2 novel mutant human adenylosuccinate lyases (ASL) associated with autism and characterization of the equivalent mutant B. subtilis ASL. J Biol Chem 279, 53789-53797

Roizen NJ, Patterson D (2003). Down’s Syndrome. Lancet 361, 1287-1295

Sean Shaheen, Ph.D.

Koese ME, Mitchell WJ, Kopidakis N, Chang CH, Shaheen SE, Kwiseon K, Rumbles G (2007). Theoretical studies on conjugated phenyl-cored thiophene dendrimers for photovoltaic applications. Journal of the American Chemical Society 129, 14257-14270

Kopidakis N, Mitchell WJ, Ginley DS, Rumbles G, Shaheen SE (2006). Bulk heterojunction organic photovoltaic devices based on phenyl-cored thiophene dendrimers. Applied Physics Letters 89, 103524

Mitchell WJ, Kopidakis N, Rumbles G, Ginley DS Shaheen SE (2005). The synthesis and properties of solution processable phenyl cored thiophene dendrimers. Journal of Materials Chemistry 15, 4518-4530

Shaheen SE, Ginley DS, Jabbour GE (2005). Organic photovoltaics: toward low-cost power generation. Materials Research Society Bulletin, January Edition

Shaheen SE, Brabec CJ, Padinger F, Fromherz T, Hummelen JC, Sariciftci NS (2001) . 2.5% efficient organic plastic solar cells. Applied Physics Letters 78, 841-843

Shaheen SE, Vangeneugden D, Kiebooms R, Vanderzande D, Fromherz T, Padinger F, Brabec CJ, Sariciftci NS (2001). Low band-gap polymeric photovoltaic devices. Synthetic Metals 121, 1583-1584

Lynn M. Taussig, M.D.

Taussig, LM and Landau, LI, (Eds).Pediatric Respiratory Medicine, 2nd Edition, Mosby/Elsevier, 2008. (Textbook)

Sorkness, C, et al. for the Childhood Asthma Research and Education Network. Long-term comparison of three controller regimens for mild-moderate persistent childhood asthma (2007). The Pediatric Asthma Controller Trial (PACT). J Allergy Clin Immunol 199, 64-72

Guilbert, TW, et al. for the Childhood Asthma Research and Education Network (2006). Long-term inhaled corticosteroids in preschool children at high risk for asthma. New Eng J Med 354, 1985-1997

Zeiger, RS, et al. for the Childhood Asthma Research and Education Network (2006). Response profiles to fluticasone and montelukast in mild to moderate persistent childhood asthma. J Allergy Clin Immunol 117, 45-52

Morgan, WJ, Stern DA, Sherrill, DL, Guerra, S, Holberg, CJ, Guilbert, TW, Taussig LM, Wright, AL, Martinez FD (2005). Outcome of asthma and wheezing in the first six years of life. Am J Respir Crit Care Med 172, 1253-1258

Rodman DM, Pollis JM, Helshe Sr., et.al. (2005). Late diagnosis defines a unique population of long-term survivors of cystic fibrosis. Am J Respir Crit Care Med 171, 621-626

Guilbert TW, et al. for the Childhood Asthma Research and Education Network (2004). The prevention of early asthma in kids study: design, rationale and methods. Control Clinical Trials 25, 286-130

Guilbert, T.W., et al. for the Childhood Asthma Research and Education Network (2004). Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J. Allergy Clin Immunol 114, 1282-1287

June 27, 2008