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Phillip B. Danielson
Professor, Department of Biological Sciences
Address and Phone Numbers:
Eleanor Roosevelt Insitute
University of Denver
2101 E. Wesley Avenue
Denver, Colorado 80208
Office: (303) 871-2899
BW221
Lab: (303) 871-3561
E-mail: pdaniels@du.edu
Research Interests:
Amyotrophic Lateral Sclerosis "Lou Gehrig's Disease"
Dr. Phillip B. Danielson has recently joined the ERI research team studying amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is known to have both sporadic and familial forms. Mutations in the copper-zinc superoxide dismutase gene (SOD1) account for 10 to 20 percent of the inherited ALS. Over 100 different mutations in the SOD1 gene can cause ALS in humans and at least 8 of these have been shown to produce an ALS-like phenotype when expressed in transgenic mice. Dr. Kunst previously found that one of these mutants (murine G86R (mG86R) SOD1) is highly dependent upon the strain background. Depending on the background, onset of ALS due to this SOD1 mutation can vary from an average of 103 days to 211 days. Dr. Kunst and her research group have isolated several modifier genes, which reflect the differences in the genetic background of certain mouse strains and are characterizing their genetic location, expression, and impact on ALS onset. Identification of modifier genes and characterization and their mechanism(s) of action may lead to as yet unidentified targets of pharmacological intervention for ALS.
Dr. Danielson teaches courses in, Virology / Infectious Human Disease, Immunology, Human Molecular Biology and Forensic Biology. His research program encompasses studies in forensic genetics and comparative proteomics - particularly the development of new technologies for the analysis of DNA mixtures.
Dr. Danielson has worked in collaboration with forensic scientists from around the world. His work has been featured in both academic and professional journals and magazines including the Proceedings of the National Academy of Sciences, The Scientist magazine, USA Today and Law Enforcement Technology magazine. He also serves a science advisor to the National Law Enforcement and Corrections Technology Center for the Rocky Mountain Region.
Degrees and Education:
- 1996 Ph.D., Biology
University of Denver - Denver, CO
- 1983 B.S., Biology
Metropolitan State College of Denver - Denver, CO
Professional Experience:
- 2007-present
Professor
Department of Biological Sciences
University of Denver
- 2003-2007
Associate Professor
Department of Biological Sciences
University of Denver
- 1997-2003
Assistant Professor
Department of Biological Sciences
University of Denver
- 1996-1997
Post-Doctoral Research Associate
Department of Biological Sciences
University of Denver
- 1994-1996
Graduate Research Assistant
Department of Biological Sciences
University of Denver
- 1991-1994
Graduate Teaching Assistant
Department of Biological Sciences
University of Denver
- 1990-1991
Research Assistant
Department of Molecular, Cellular and Developmental Biology
University of Colorado
- 1985-1990
CEO/Instructor
CEC Foreign Language Center
- 1984-1986
Instructor
CEC Foreign Language Center
- 1984-1985
Research Student
Department of Biochemistry and Biophysics
University of Tokyo
- 1983-1984
Science Instructor
Edwin C. Johnson Junior/Senior High School
- 1983-1984
Science Instructor
West Senior High School
Recent Publications:
(Abstracts of some articles are available)
- Danielson, P.B. and Kristinsson, R. (2007) Detection of Sequence Polymorphisms in the HV1 and HV2 Regions of Human Mitochondrial DNA by Denaturing High-Performance Liquid Chromatography. Journal of Forensic Sciences (In Press)
- Danielson, P.B., Sun, H-Y, Melton, T., and Kristinsson, R. (2007) Resolving mtDNA Mixtures by Denaturing High-Performance Liquid Chromatography and Linkage Phase Determination. FSI Genetics 1:148-153. (INVITED MANUSCRIPT)
- Westring, CG, Kristinsson, R., Gilbert, DM, and Danielson, P.B. (2007) Reduced Volume Protocol for Optimized Quantification of Genomic DNA using the Quantifiler™ Human DNA kit. Journal of Forensic Science (In Press)
- Danielson, P.B. (2005) Mitochondrial DNA Analysis by Denaturing High-Performance Liquid Chromatography for the Characterization and Separation of Mixtures in Forensic Samples. Peer reviewed report for electronic release under NIJ cover.
- Danielson, P.B., Kristinsson, R., Shelton, R.J. and LaBerge, G.S. (2005) Separating Human DNA Mixtures using Denaturing High-Performance Liquid Chromatography (DHPLC). Expert Review of Molecular Diagnostics 5(1):53-63. INVITED REVIEW ARTICLE
- Khalap A., Bagrosky, B., Lecaude, S., Youson, J, Danielson, P., and Dores, R.M. (2005) Trends in the Evolution of the Proenkephalin and Prodynorphin Genes in Gnathostomes. Proceedings of the New York Academy of Science, 1040:22-37.
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